# Evermore Aesthetics: beauty under repair

> Evermore Aesthetics follows GHK-Cu from collagen cultures to skin and hair studies, with an eye for the work beneath appearances.

**Skin, copper and the work of repair**

Lasting beauty is an appealing idea. Repair has my closer attention.

### [Collagen cultures](/collagen)

The cell experiment that started this file, followed by the less tidy work of tissue remodelling.

### [Cosmetic skin results](/skin-results)

Procollagen, fine lines and the percentages attached to treated subjects.

### [Copper crossing skin](/skin-delivery)

A skin-layer experiment and the practical problem of getting a peptide to its destination.

### [The hair-count trial](/hair-study)

A human combination study, and a neighbouring copper peptide with a different name.

## GHK-Cu and skin repair

Evermore is a lavish word to attach to a face. It suggests a finish that stays finished. Maintenance suits my temperament: the less glamorous business of making, clearing away and making again.

The copper peptide GHK-Cu gives that interest somewhere concrete to go. A [review of tissue remodelling describes increased synthesis of collagen and elastin alongside matrix metalloproteinases and anti-proteases](https://pubmed.ncbi.nlm.nih.gov/18644225/). Those last groups include enzymes that break down tissue's surrounding material and proteins that restrain that breakdown. There is a great deal happening beneath the agreeable word ‘repair’.

I like this untidy picture. An aesthetic ideal can look static; the biology described in these experiments is busy. That is an interpretation of the research, and the reason this archive begins with GHK-Cu.

## Collagen production in culture

The [early collagen experiment used human fibroblasts in culture](https://pubmed.ncbi.nlm.nih.gov/3169264/). GHK-Cu increased collagen synthesis without changing the number of cells. That is a wonderfully specific result to start with: something changed in what the cells were making.

A face contains more complications than a culture dish. Still, I give that experiment real weight because its question was manageable and its answer precise. The [collagen file](/collagen) follows this finding into the wider account of tissue remodelling.

## The research files

The clinical material introduces a different kind of interest. A [review reports increased procollagen synthesis in a share of treated subjects](https://pmc.ncbi.nlm.nih.gov/articles/PMC11830136/), while a [skin-layer experiment follows copper entering and remaining in human skin outside the body](https://pmc.ncbi.nlm.nih.gov/articles/PMC3016279/). The measured substance, the setting and the outcome each change the story.

Particulars suit me. A cream result has its own texture; so does a hair trial testing a mixture. The files below follow those separate subjects far enough to make them interesting. The grand word in the site's name can wait while the smaller findings have their say.

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At Evermore Aesthetics I sift published research on skin and repair for an editorial archive, with no aesthetics business or medical advice behind the name.